You are viewing this page in draft mode. Birth Defects Res. If the p53 deletion accurately models the female bias in neural tube closure defects, then the greater female susceptibility may reside in X genes related to X-inactivation or cell death.
Thus, the FCG model confirmed that most of these phenotypes are sexually differentiated because of the action of gonadal hormones. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. Testing for this interaction is a major advantage of the FCG model.
Arnold AP. Sex, neural tube defects, and multisite closure of the human neural tube. The sex chromosome effect that differentiates XX and XY dopamine cells in vitro, however, cannot be explained by a direct effect of Sry.
The results suggest that mice with different sex chromosomes have differences in the rate at which they learn a habit. Jegalian, K. A Yin-Yang effect between sex chromosome complement, sex hormones on the immune response. Hojo, Y. Cell 6— Anders S. Figure 3: Sex chromosome effect on dopamine neurons.
Taken together, these results strongly suggest that compensation of aneuploidy varies among genotypes. Existing mouse lines and transgenic technologies are sufficient to allow one to determine whether the sex chromosome effect is an X or Y effect, and then narrow the list of candidate genes until the relevant genes are identified e.
The development and testing of the FCG mice has been the result of a large collaborative effort across numerous labs. Search Menu. Nature Neurosci.